Product Identification
【Product Name】naprosyn
【Synonyms】Diocodal；dl-萘普生
【CAS】22204-53-1
【Formula】C14H14O3
【Molecular Weight】230.26
【EINECS】244-838-7
【RTECS】UF5275000
【RTECS Class】Drug; Mutagen; Reproductive Effector; Human Data
【Merck】12,6504
【Beilstein/Gmelin】3591067
Physical and Chemical Properties
【Appearance】Crystals from acetone-hexane. Practically odorless.
【Solubility in water】Insoluble
【Melting Point】156℃
【Boiling Point】404℃
【Vapor Pressure】3E-7 (25℃)
【pKa/pKb】4.15 (pKa)
【Partition Coefficient】3.24
【Heat Of Vaporization】69.1 kJ/mol
【Usage】Anti-inflammatory drug.
First Aid Measures
【Ingestion】Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
【Inhalation】If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
【Skin】Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
【Eyes】If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.
Handling and Storage
【Storage】Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
【Handling】All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Hazards Identification
【Inhalation】Apnea has developed secondary to seizures following overdose. - Pulmonary infiltrates with eosinophilia has occurred with chronic therapeutic use. Bronchoconstriction and asthma has been reported after initial dosing.
【Skin】Photosensitivity and pseudoporphyria has been described in chronic therapeutic use. Necrotizing vasculitis has been reported with short term use.
【EC Risk Phrase】R 22 36/37/38
【EC Safety Phrase】S 26 36/37/39
Exposure Controls/Personal Protection
【Personal Protection】Chemical splash ggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
【Respirators】Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
【Exposure Effects】CNS depression and seizures (focal and generalized) have occurred following overdose. A. Dizziness and dystonic movement disorders have also been reported. With therapeutic use - aseptic meningitis has been associated with naproxen. Naproxen is pregnancy catery B.
1. Risk Factor D if used in 3rd trimester or near delivery.
Because of known effects of the fetus (closure of ductus arteriosus), it should be avoided during late pregnancy.
Naproxen has been found in the milk of lactating women; however, The American Academy of Pediatrics considers naproxen to be compatible with breast feeding (Briggs et al, 1998).
Fire Fighting Measures
【Flash Point】155℃
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Accidental Release Measures
【Small spills/leaks】Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability and Reactivity
【Stability】No data.
【Incompatibilities】Strong oxidizing agents.