丙硫氧嘧啶安全技术说明书
Product Identification
【Product Name】2-Mercapto-6-propylpyrimid-4-one
【Synonyms】Procasil
【CAS】51-52-5
【Formula】C7H10N2OS
【Molecular Weight】170.23
【EINECS】200-103-2
【RTECS】YR1400000
【RTECS Class】Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
【Merck】12,8054
【Beilstein/Gmelin】130039
【Beilstein Reference】5-24-07-00257
【EC Class】harmful

Physical and Chemical Properties
【Appearance】Odorless white crystalline powder of starch-like appearance. Bitter taste. Saturated solution is neutral or slightly acid to litmus.
【Solubility in water】Slightly soluble
【Melting Point】215 - 218
【Boiling Point】448
【Vapor Pressure】0.54 (25 C)
【pKa/pKb】7.63 (pKa)
【Partition Coefficient】1.37
【Usage】Medication.

First Aid Measures
【Ingestion】If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
【Inhalation】Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
【Skin】Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
【Eyes】Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage
【Storage】Store in a cool, dry place. Keep container closed when not in use. Hormones and antibiotics room.
【Handling】Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification
【Ingestion】See inhalation.
【Inhalation】Symptoms of exposure to this compound include recurrent painful skin lesions, fatigue, migratory polyanthralgias of hands and knees, palpable spleen, splenomegaly, amenorrhea, low-grade fever, gingivostomatitis, weakness, weight loss, dark red-brown colored urine, necrotizing vasculitis, leukopenia, cutaneous vasculitis, nasal congestion, enlarged thyroid, necrotic ulcerations on the lower extremities, bloody nasal discharge and cough.
【Skin】Skin rashes may occur secondary to hematologic toxicity during chronic therapy.
【Eyes】See inhalation
【EC Risk Phrase】R 22
【EC Safety Phrase】S 24/25

Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear chemical ggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
【Respirators】A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Fire Fighting Measures
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire.

Accidental Release Measures
【Small spills/leaks】Clean up spills immediately, using the appropriate protective equipment.

Stability and Reactivity
【Incompatibilities】Incompatible with strong oxidizing agents, strong acids and strong bases Reacts with sulfhydryl-oxidizing agents.
【Stability】Stable under normal temperatures and pressures.
【Decomposition】Irritating and toxic fumes and gases.

Transport Information
【HS Code】2933 59 95